Sialinbalance · 载衡生物

Repair and regeneration — starting with your mouth.

A biotech company turning two decades of research into everyday oral care, and beyond.

01 — Oral care

When the mouth loses its balance, everyday comfort quietly slips away.

Does any of this sound like you?

01
That sharp wince from cold or heat
Teeth that twinge at a cold drink, a hot sip, or a sweep of the brush — the hallmark of dentinal sensitivity.
Research-backed
02
Gums quietly pulling back
Gums that recede, gaps that widen, roots that begin to show — teeth that feel more exposed than before.
03
Sore spots that keep coming back
Recurring mouth discomfort — tender areas that flare, ease, and return, sensitive to the lightest touch.
04
A mouth that feels fragile under stress
When stress runs high or hormones shift, the mouth can feel especially fragile — a sign its balance is under strain.
05
Dryness and fragile tissue during radiotherapy
Dry mouth and delicate oral tissue during radiotherapy or chemotherapy — a setting our research has studied closely.
Research-backed
06
Hard-to-manage care for fragile mouths
In critical illness or bed-bound care, keeping the mouth comfortable and intact is difficult, and easily overlooked.
07
Loosening teeth as the years add up
With age, teeth can loosen and the bone that anchors them gradually thins — tissue slowly drifting out of balance.

Our difference

Most mouthwashes kill bacteria — the good with the bad. We take a different path: not killing, but rebalancing. A regulatory approach designed to help the mouth restore its own balance and repair.

What "balance" means in the mouth

Your mouth is home to the second most diverse microbial community in the body, after the gut: more than 700 species of bacteria, alongside fungi, viruses and archaea, living in distinct neighborhoods — the tooth surface, the tongue, the gumline, the cheek — each with its own residents. These microbes aren't simply "good" or "bad." Many earn their keep: some crowd out harmful strains, and a specialized group of nitrate-reducing bacteria starts the pathway that turns dietary nitrate into nitric oxide[4]. Health isn't the absence of bacteria — it's a stable, balanced community. When that balance tips, problems follow: a state scientists call dysbiosis.

Our repair direction

Our first application focuses on dentin–pulp and oral-tissue homeostasis: designed to promote tubule occlusion and support mineralized repair, and to support comfort and tissue stability — addressing the mechanisms behind dentinal sensitivity, rather than masking them.

Dentinal tubules open as enamel wears or the gum line recedes.healthy · ≈ 0.4 µm → exposed · ≈ 0.8 µm · flow ×16

The direction we work in: open tubules progressively occluded by mineral, damping the fluid movement behind dentinal sensitivity.

Schematic illustrations, not experimental data.

Why you can trust it

Backed by peer-reviewed research — including salivary nitrate protecting the salivary gland[6] and nitrate–Sialin dentin regeneration[9]. See the full record below.

See the full research record →

02 — The nitrate mystery

A mystery in your saliva.

01 · the hoard
Your salivary glands concentrate nitrate up to ten times the level in your blood[4]. Why would the body work so hard to hoard it?
02 · the suspicion
For decades, dietary nitrate was seen as something to avoid — even harmful.
03 · the search
Our academician team spent more than twenty years asking why[1].
04 · the answer
The answer: this "unwanted" nitrate is a raw material for nitric oxide[4] — a molecule essential to life, blood flow, and healing.
05 · the gate
And the gate that lets it in is a transporter called Sialin[2] — which the body makes less of as we age[10]. Restore the pathway, and you help the mouth repair itself.

03 — The science

The science, in one line.

Oral cycle The glands concentrate nitrate, saliva carries it, and the loop closes through the body.

Act I · Oral cycle · 0:00

The glands concentrate nitrate, saliva carries it, and the loop closes through the body.
JDR 2003
A transporter, not a channel: bind, change shape, release inside, close.
PNAS 2012
One anion, many tissues: the same signal appears in bone, immune cells and glands.
2013 – 2026
Beyond transport: a sensing role reaching the cell's organelles and metabolism.
2025 – 2026
Sialintide, our designed molecule, brought onto the same pathway.
Our work

Salivary nitrate is carried into cells by a transporter called Sialin (SLC17A5)[2], where it helps tissues stay in balance and repair. Sialintide is our designed molecule built on this pathway.

Nitratein salivaSialinthe transporter gateBalance & repairin the tissueSialintideour designed molecule

Beyond transport, our latest work describes a nitrate-sensing role reaching into the cell's organelles and metabolism[6][9][10]. Sialin is a transporter, not a channel; Sialintide is a separate molecule designed on the same pathway.

Film is illustration, not experimental data · the chapters carry the text

04 — More applications

One pathway, many tissues.

The same nitrate–Sialin biology reaches beyond the mouth. A few directions we are exploring:

Engraved plate · an illustration, not data

01
Hair & Scalp
Supporting scalp balance and healthy hair.
In development
02
Metabolism & Energy
Exploring nitrate biology for metabolic balance[5].
In research
03
Bone
Nitrate–Sialin signaling in bone homeostasis[10].
Early research
04
Beyond
One pathway, many tissues. More to come.
Exploratory

Move your pointer — you are the light

05 — Scientific strength

Sialinbalance · Research recordVol. 23 · 2003 — 2026Published · peer-reviewed

Twenty-three years, one line of discovery.

Published, peer-reviewed research from an academician team. Titles link to PubMed where available.

Table 1 The programme in numbers

0yrs

Years of research

2003 — 2026, one line of work

Related patents

across the programme

0×JDR

Papers in JDR

Journal of Dental Research

0PNAS

Sialin identified

as a nitrate transporter

Abstract

Explore the peer-reviewed record below. In 2003 the programme showed that destroying the parotid glands disturbs nitrate and nitrite metabolism[1]. In 2012 it identified Sialin (SLC17A5) as a nitrate transporter in the plasma membrane[2]. The line has since run through salivary nitrate under stress[3] and the nitrate-to-nitric-oxide route[4], and, in 2025 – 2026, through metabolic[5], mitochondrial[6], myelin[7], mucosal[8], dentin[9] and bone[10] homeostasis, and human dentinogenesis[11].

Fig. 1 · The record, 2003 – 2026. One mark per paper on the year it appeared; the hairline joins them in order of publication. Hover a mark or a reference.

References

Destruction of parotid glands affects nitrate and nitrite metabolism
J Dent Res2003PMID 12562881 Where the 23-year program began
Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane
PNAS2012PMID 22778404 The paper that named Sialin
Active secretion and protective effect of salivary nitrate against stress
Free Radic Biol Med2013Salivary nitrate protects under stress
From Nitrate to Nitric Oxide: the Role of Salivary Glands and Oral Bacteria
J Dent Res2016PMID 27872324 Foundational nitrate–NO review
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance
Signal Transduct Target Ther2025Macrophage rebalance in metabolic syndrome
Nitrate maintains mitochondrial membrane integrity via Sialin-FKBP8 granules
Redox Biology2025Mitochondrial membrane integrity
Nitrate ameliorates myelin loss and cognitive impairment in Alzheimer's disease
Science Bulletin2025Myelin loss & cognition
Salivary Nitrate Maintains Mucosal Homeostasis via the Sialin–Neuropeptide Axis
J Dent Res2026PMID 40977421 Salivary nitrate & mucosal homeostasis
Nitrate-Sialin Promotes Dentin Regeneration via Mitochondrial Rewiring
J Dent Res2026PMID 42206542 Nitrate–Sialin & dentin regeneration
Sialin-STAT3 axis regulates bone homeostasis in mice
Bone Research2026Sialin–STAT3 in bone homeostasis
Spatiotemporal interplay drives human dentinogenesis
Nature Communications2026Human dentinogenesis

Repair and regeneration — starting with your mouth.

When the mouth loses its balance, everyday comfort quietly slips away.

That sharp wince from cold or heat

Gums quietly pulling back

Sore spots that keep coming back

A mouth that feels fragile under stress

Dryness and fragile tissue during radiotherapy

Hard-to-manage care for fragile mouths

Loosening teeth as the years add up

A mystery in your saliva.

The science, in one line.

Act IOral cycle

Act IISialin transport

Act IIIHomeostatic states

Act IVNitrate sensing

Act VTranslational handle

One pathway, many tissues.

Hair & Scalp

Metabolism & Energy

Bone

Beyond

Twenty-three years, one line of discovery.

Correspondence